====== David Lee ======

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===== Post Doctoral Research Fellow =====

I work for the [[http://www.mcsg.anl.gov/|Midwest Center for Structural Genomics (MCSG)]]. My responsibilities include selecting protein targets for structure determination, monitoring the success of target selection strategies, and providing homology models of relatives of MCSG structures.

===== Academic Background =====

1985 BSc in Biochemistry at UCL

1988 Fellowship of the Institute of Medical Laboratory Science (Virology) at NESCOT while working at the Royal Free Hospital

1995 Part-time MSc in Computer Modelling of Molecular and Biological Processes at Birkbeck (Distinction)

1999 PhD with Julia Goodfellow at Birkbeck

For my PhD I used various computational approaches to model the conformational change in transferrin that accompanies release of iron in response to a reduction in pH.

{{:cathteam:transferrin.gif|}}

After hypothesizing a mechanism of action I succeeded in simulating a small conformational change using molecular dynamics. This exhibited some of the correct features; in particular there was a hinge axis between the two halfs of the domain and it almost intersected with the crystallographic hinge axis.

===== Current Research Interests =====

Protein function prediction. I am pursuing an approach to target selection in structural genomics that targets representatives of the functional diversity of protein domain sequences predicted to belong to large structural superfamilies.

===== Selected Publications =====

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===== Other Interests =====

Most of my free time is spent helping out my partner with her horse.

===== Other CATH Team Members =====

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