{{tag>beta}}
======  Jelly Roll  =======

This is a fold topology that classically consists of four
Greek key [[glossary: motif | motifs]] that adopt an eight-stranded [[glossary:beta_sandwich | beta sandwich ]] structure.  In this fold the [[glossary:hydrogen_bond | hydrogen bonding]]
pattern between adjacent strands is broken in two places, and as a consequence the
structure comprises two four-stranded beta sheets. Both sheets are purely antiparallel,
with strands adjacent in sequence appearing in different sheets with the exception of the
fourth and fifth strands, which are in the same sheet. This leads to a structure  with only
one hairpin; all other beta-beta connections are arches. When the structure is depicted
in two-dimensions the origin of its name is apparent: the structure resembles a jelly roll (Swiss roll).

{{ :glossary:jelly_roll2.gif?800 |}}

In theory there are four types of jellyroll folds: two
have a right-handed superhelical twist, and two have a left handed twist. However, as
with the [[glossary:beta_alpha_beta_motif | beta-alpha-beta motif ]], only right-handed [[glossary:greek_key | Greek key]]
and jellyroll structures are actually observed in globular proteins. In practise,
the jelly roll may be varied by the addition or deletion of secondary
structure elements.

The example shown is a the carboxy-terminal domain of phosphomannose isomerase (CATH domain ID 1pmiA03).

{{cath:feature>1pmiA03}}


===== References =====

{{pubmed>long:1644197}}