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cathteam:lee [2008/08/02 12:23]
dlee 		cathteam:lee [2008/08/14 11:34] (current)
dlee
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 +====== David Lee ======
 +
 +{{ :cathteam:david_lee.jpg| }}
 +
 +===== Post Doctoral Research Fellow =====
 +
 +I work for the [[http://www.mcsg.anl.gov/|Midwest Center for Structural Genomics (MCSG)]]. My responsibilities include selecting protein targets for structure determination, monitoring the success of target selection strategies, and providing homology models of relatives of MCSG structures.
 +
 +===== Academic Background =====
 +
 +1985 BSc in Biochemistry at UCL
 +
 +1988 Fellowship of the Institute of Medical Laboratory Science (Virology) at NESCOT while working at the Royal Free Hospital
 +
 +1995 Part-time MSc in Computer Modelling of Molecular and Biological Processes at Birkbeck (Distinction)
 +
 +1999 PhD with Julia Goodfellow at Birkbeck
 +
 +For my PhD I used various computational approaches to model the conformational change in transferrin that accompanies release of iron in response to a reduction in pH.
 +
 +{{:cathteam:transferrin.gif|}}
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 +After hypothesizing a mechanism of action I succeeded in simulating a small conformational change using molecular dynamics. This exhibited some of the correct features; in particular there was a hinge axis between the two halfs of the domain and it almost intersected with the crystallographic hinge axis.
 +
 +===== Current Research Interests =====
 +
 +Protein function prediction. I am pursuing an approach to target selection in structural genomics that targets representatives of the functional diversity of protein domain sequences predicted to belong to large structural superfamilies.
 +
 +===== Selected Publications =====
 +
 +{{pubmed>long:18037900}}
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 +{{pubmed>long:16524831}}
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 +{{pubmed>long:16481312}}
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 +{{pubmed>long:16381865}}
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 +{{pubmed>long:15768405}}
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 +{{pubmed>long:15608188}}
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 +{{pubmed>long:15128436}}
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 +{{pubmed>long:14681381}}
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 +{{pubmed>long:12938085}}
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 +{{pubmed>long:12831888}}
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 +{{pubmed>long:12520054}}
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 +{{pubmed>long:11875040}}
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 +{{pubmed>long:11790833}}
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 +{{pubmed>long:11788987}}
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 +{{pubmed>long:11125098}}
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 +{{pubmed>long:11125070}}
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 +{{pubmed>long:10592246}}
 +
 +===== Other Interests =====
 +
 +Most of my free time is spent helping out my partner with her horse.
 +
 +===== Other CATH Team Members =====
 +
 +~~DIR?cols=page;description&hdrs=Person; Description~~
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