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glossary:beta_bulges [2008/09/17 09:51] garner |
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+ | {{tag>beta}} | ||
+ | ====== Beta Bulges ======= | ||
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+ | Beta bulges are regions of irregularity in a [[glossary:beta_sheet | beta sheet]], where the | ||
+ | normal pattern of [[glossary:hydrogen_bond | hydrogen bonding]] is disrupted, e.g. by the insertion of | ||
+ | an extra residue. A bulge usually involves two or more residues in | ||
+ | the bulged [[glossary:beta_strand | strand]], opposite a single residue in the adjacent strand. | ||
+ | These irregularities have been identified and classified | ||
+ | automatically. In all, five types of beta-bulge were identified: | ||
+ | classic, G1, wide, bent and special. Bulges were found to occur | ||
+ | frequently in proteins, on average more than two bulges per protein. | ||
+ | In general, beta-bulges produce two main | ||
+ | changes in the structure of a beta sheet: (i)disruption of the normal alternation | ||
+ | of side-chain direction (ii) accentuation of the twist of the sheet, altering | ||
+ | the direction of the surrounding strands. | ||
+ | |||
+ | ===== References ===== | ||
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+ | {{pubmed>long:275827}} | ||
+ | {{pubmed>long:8251933}} | ||
+ | |||