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glossary:four_helix_bundle [2008/08/11 11:13] cuff |
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+ | {{tag>alpha}} | ||
+ | ====== Four Helix Bundle ======= | ||
+ | |||
+ | Four [[glossary:alpha_helix | helix]] bundles are a common structural [[glossary:motif | motif]] or architecture | ||
+ | that has been extensively documented. They can be observed both independently and as components of larger folding units. The motif comprises four helices | ||
+ | packed together in a variety of different ways, forming a hydrophobic core. In the most common | ||
+ | bundles, the helices that are adjacent in the amino acid sequence are also adjacent in the | ||
+ | three dimensional structure, forming the so-called up-down-up-down four helix bundle. | ||
+ | The side chains of each helix in the bundle are arranged | ||
+ | such that the hydrophobic side chains are buried between the helices and the hydrophilic | ||
+ | side chains are exposed on the surface of the bundle. | ||
+ | The example shown is a transferase (CATH domain ID 1tqgA00). | ||
+ | |||
+ | {{cath:feature>1tqgA00}} | ||
+ | |||
+ | ===== References ===== | ||
+ | |||
+ | {{pubmed>long:1323830}} | ||
+ | {{pubmed>long:3380793}} | ||
+ | {{pubmed>long:2771946}} | ||
+ | {{pubmed>long:8388289}} | ||
+ | {{pubmed>long:6251384}} | ||