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+====== David Lee ======
+{{ :cathteam:david_lee.jpg| }}
+===== Post Doctoral Research Fellow =====
+I work for the [[http://www.mcsg.anl.gov/|Midwest Center for Structural Genomics (MCSG)]]. My responsibilities include selecting protein targets for structure determination, monitoring the success of target selection strategies, and providing homology models of relatives of MCSG structures.
+===== Academic Background =====
+BSc in Biochemistry at UCL
+Fellowship of the Institute of Medical Laboratory Science (Virology) at NESCOT while working at the Royal Free Hospital
+Part-time MSc in Computer Modelling of Molecular and Biological Processes at Birkbeck (Distinction)
+PhD with Julia Goodfellow at Birkbeck
+For my PhD I used various computational approaches to model the conformational change in transferrin that accompanies release of iron in response to a reduction in pH.
+{{:cathteam:transferrin.gif|}}
+After hypothesizing a mechanism of action I succeeded in simulating a small conformational change using molecular dynamics. This exhibited some of the correct features; in particular there was a hinge axis between the two halfs of the domain and it almost intersected with the crystallographic hinge axis.
+===== Current Research Interests =====
+Protein function prediction. I am pursuing an approach to target selection in structural genomics that targets representatives of the functional diversity of protein domain sequences predicted to belong to large structural superfamilies.
+===== Selected Publications =====
+{{pubmed>long:18037900}}
+{{pubmed>long:16524831}}
+{{pubmed>long:16481312}}
+{{pubmed>long:16381865}}
+{{pubmed>long:15768405}}
+{{pubmed>long:15608188}}
+{{pubmed>long:15128436}}
+{{pubmed>long:14681381}}
+{{pubmed>long:12938085}}
+{{pubmed>long:12831888}}
+{{pubmed>long:12520054}}
+{{pubmed>long:11875040}}
+{{pubmed>long:11790833}}
+{{pubmed>long:11788987}}
+{{pubmed>long:11125098}}
+{{pubmed>long:11125070}}
+{{pubmed>long:10592246}}
+===== Other Interests =====
+Most of my free time is spent helping out my partner with her horse.
+===== Other CATH Team Members =====
+~~DIR?cols=page;description&hdrs=Person; Description~~

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