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--- glossary:beta_bulges [2008/08/11 08:57] – cuff
+++ glossary:beta_bulges [2008/09/17 09:08] (current) – garner
@@ Line 1: / Line 1: @@
+{{tag>beta}}
+====== Beta Bulges =======
+Beta bulges are regions of irregularity in a [[glossary:beta_sheet | beta sheet]], where the
+normal pattern of [[glossary:hydrogen_bond | hydrogen bonding]] is disrupted, e.g. by the insertion of
+an extra residue. A bulge usually involves two or more residues in
+the bulged [[glossary:beta_strand | strand]], opposite a single residue in the adjacent strand.
+These irregularities have been identified and classified
+automatically. In all, five types of beta-bulge were identified:
+classic, G1, wide, bent and special. Bulges were found to occur
+frequently in proteins, on average more than two bulges per protein.
+In general, beta-bulges produce two main
+changes in the structure of a beta sheet: (i)disruption of the normal alternation
+of side-chain direction (ii) accentuation of the twist of the sheet, altering
+the direction of the surrounding strands.
+===== References =====
+{{pubmed>long:275827}}
+{{pubmed>long:8251933}}

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