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--- glossary:jelly_roll [2008/08/11 10:59] – cuff
+++ glossary:jelly_roll [2008/09/19 08:05] (current) – garner
@@ Line 1: / Line 1: @@
+{{tag>beta}}
+======  Jelly Roll  =======
+This is a fold topology that classically consists of four
+Greek key [[glossary: motif | motifs]] that adopt an eight-stranded [[glossary:beta_sandwich | beta sandwich ]] structure.  In this fold the [[glossary:hydrogen_bond | hydrogen bonding]]
+pattern between adjacent strands is broken in two places, and as a consequence the
+structure comprises two four-stranded beta sheets. Both sheets are purely antiparallel,
+with strands adjacent in sequence appearing in different sheets with the exception of the
+fourth and fifth strands, which are in the same sheet. This leads to a structure  with only
+one hairpin; all other beta-beta connections are arches. When the structure is depicted
+in two-dimensions the origin of its name is apparent: the structure resembles a jelly roll (Swiss roll).
+{{ :glossary:jelly_roll2.gif?800 |}}
+In theory there are four types of jellyroll folds: two
+have a right-handed superhelical twist, and two have a left handed twist. However, as
+with the [[glossary:beta_alpha_beta_motif | beta-alpha-beta motif ]], only right-handed [[glossary:greek_key | Greek key]]
+and jellyroll structures are actually observed in globular proteins. In practise,
+the jelly roll may be varied by the addition or deletion of secondary
+structure elements.
+The example shown is a the carboxy-terminal domain of phosphomannose isomerase (CATH domain ID 1pmiA03).
+{{cath:feature>1pmiA03}}
+===== References =====
+{{pubmed>long:1644197}}

CATH

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