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--- glossary:loop [2008/08/06 16:11] – cuff
+++ glossary:loop [2008/09/19 10:39] (current) – garner
@@ Line 1: / Line 1: @@
+{{tag>structure}}
+====== Loop =======
+A protein loop is any stretch of non-regular polypeptide chain connecting
+secondary structures.
+__Short loops__ commonly have little structure and are often found joining two adjacent [[glossary:beta_strand | beta strands ]]. They are often referred to as reverse turns.
+__Long loops__ are often flexible and are able to adopt a number of different conformations, effectively making them invisible in x-ray crystal structures. These loops are likely to be involved in protein function and can switch from a 'open' conformation (frequently to allow access to an active site) to a 'closed' conformation (to protect reactive groups from bulk solvent).
+===== References =====
+{{pubmed>long:4010788}}
+{{pubmed>long:8819975}}
+{{pubmed>long:3775366}}

CATH