David Lee

I work for the Midwest Center for Structural Genomics (MCSG). My responsibilities include selecting protein targets for structure determination, monitoring the success of target selection strategies, and providing homology models of relatives of MCSG structures.

1985 BSc in Biochemistry at UCL

1988 Fellowship of the Institute of Medical Laboratory Science (Virology) at NESCOT while working at the Royal Free Hospital

1995 Part-time MSc in Computer Modelling of Molecular and Biological Processes at Birkbeck (Distinction)

1999 PhD with Julia Goodfellow at Birkbeck

For my PhD I used various computational approaches to model the conformational change in transferrin that accompanies release of iron in response to a reduction in pH.

After hypothesizing a mechanism of action I succeeded in simulating a small conformational change using molecular dynamics. This exhibited some of the correct features; in particular there was a hinge axis between the two halfs of the domain and it almost intersected with the crystallographic hinge axis.

Protein function prediction. I am pursuing an approach to target selection in structural genomics that targets representatives of the functional diversity of protein domain sequences predicted to belong to large structural superfamilies.

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Most of my free time is spent helping out my partner with her horse.

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