I work as part of the Midwest Consortium for Structural Genomics, aiding target selection and analysis of the novelty of the protein structures they produce. In parallel, I also develop methods for homology recognition and function prediction from protein structure and sequence.
My PhD was focussed on developing novel methods to enhance the speed of structure classification in the CATH database. With this aim, I developed the structure comparison method CATHEDRAL to effectively decompose whole protein structures into their component domains. I have also been involved with the analysis of large, functional diverse domain superfamilies in CATH, and as a consequence have developed a method called FLORA to discriminate between differetn functional families within these superfamilies.
long:19714201 long:18996897 long:18554899 long:18052539 long:18037900 long:16780872
Current affairs, comedy, whiskey.
~~DIR?cols=page;description&hdrs=Person; Description~~