====== CATH Release Notes ====== The CATH database is constantly being updated through automated algorithms and manual curation. The most up-to-date annotations can be found in the [[data:index | CATH daily snapshots]] where we provide a limited amount of information (domain boundaries and superfamily assignments) for the very latest snapshot of the current database. We also provide major releases (CATH-Plus) where we take a branch of the database through the full release process: adding internal checks, associating functional and sequence annotations, creating datasets, and so on. Information from all releases can be downloaded from the [[data:index| Download]] page, general stats on each CATH-Plus release is provided below. ===== CATH-Plus Version 4.3 ===== **Based on PDB release: July 01, 2019** Changes since v4.2: * 65,381 newly classified domains * 25,311 newly processed PDBs ^ Class ^ Architecture ^ Topology ^ Homologous Superfamily ^ S35 Family ^ S60 Family ^ S95 Family ^ S100 Family ^ Domains ^ | Class 1 | 5 | 404 | 2033 | 7817 | 10238 | 13421 | 26121 | 103788 | | Class 2 | 21 | 244 | 1290 | 6998 | 9877 | 16235 | 29211 | 124032 | | Class 3 | 14 | 634 | 2337 | 16373 | 24356 | 31614 | 64907 | 262275 | | Class 4 | 1 | 108 | 181 | 386 | 497 | 676 | 1112 | 5716 | | Class 6 | 2 | 82 | 790 | 814 | 867 | 969 | 1376 | 4427 | | **TOTAL** | **41** | **1390** | **6631** | **32388** | **45835** | **62915** | **122727** | **500238** | ===== CATH-Plus Version 4.2 ===== **Based on PDB release: July 01, 2017** Changes since v4.1: * 125,858 newly classified domains * 24,765 newly processed PDBs ^ Class ^ Architecture ^ Topology ^ Homologous Superfamily ^ S35 Family ^ S60 Family ^ S95 Family ^ S100 Family ^ Domains ^ | Class 1 | 5 | 405 | 2174 | 7771 | 9948 | 12797 | 24176 | 90302 | | Class 2 | 21 | 244 | 1395 | 7011 | 9627 | 15169 | 26904 | 110260 | | Class 3 | 14 | 634 | 2428 | 16196 | 23313 | 29670 | 60020 | 229776 | | Class 4 | 1 | 108 | 122 | 311 | 399 | 542 | 876 | 4519 | | **TOTAL** | **41** | **1391** | **6119** | **31289** | **43287** | **58178** | **111976** | **434857** | ===== CATH-Plus Version 4.1 ===== **Based on PDB release: Jan 01, 2015** Changes since v4.0: * 73,141 newly classified domains * 17,444 newly processed PDBs ^ Class ^ Architecture ^ Topology ^ Homologous Superfamily ^ S35 Family ^ S60 Family ^ S95 Family ^ S100 Family ^ Domains ^ | Class 1 | 5 | 396 | 908 | 4645 | 6190 | 8174 | 16299 | 61579 | | Class 2 | 20 | 241 | 547 | 4641 | 6639 | 10687 | 18460 | 78049 | | Class 3 | 14 | 628 | 1160 | 11617 | 17134 | 21834 | 44966 | 165745 | | Class 4 | 1 | 108 | 122 | 252 | 322 | 442 | 697 | 3626 | | **TOTAL** | **40** | **1373** | **2737** | **21155** | **30285** | **41137** | **80422** | **308999** | ===== CATH-Plus Version 4.0 ===== **Based on PDB release: March 26, 2013** Changes since v3.5: * 62,322 newly assigned domains * 112 new homologous superfamilies * 62 new folds (topologies) ^ Class ^ Architecture ^ Topology ^ Homologous Superfamily ^ S35 Family ^ S60 Family ^ S95 Family ^ S100 Family ^ Domains ^ | Class 1 | 5 | 397 | 907 | 3879 | 5118 | 6737 | 13368 | 48121 | | Class 2 | 20 | 241 | 547 | 3650 | 5221 | 8373 | 14526 | 58944 | | Class 3 | 14 | 626 | 1158 | 9171 | 13415 | 17047 | 35313 | 125772 | | Class 4 | 1 | 111 | 126 | 233 | 293 | 410 | 651 | 3021 | | **TOTAL** | **40** | **1375** | **2738** | **16933** | **24047** | **32567** | **63858** | **235858** | ===== CATH-Plus Version 3.5 ===== **Based on PDB release: Sept 20, 2011** Changes since v3.4: * 20,616 newly assigned domains * 77 new homologous superfamilies * 31 new folds (topologies) The table below summarises the number of clusters within each of the four classes in CATH. ^ Class ^ Architecture ^ Topology ^ Homologous Superfamily ^ S35 Family ^ S60 Family ^ S95 Family ^ S100 Family ^ Domains ^ | 1 | 5 | 386 | 875 | 2917 | 3843 | 5069 | 10098 | 37038 | | 2 | 20 | 229 | 520 | 2618 | 3796 | 6147 | 10744 | 43881 | | 3 | 14 | 594 | 1113 | 6183 | 9107 | 11668 | 24452 | 90029 | | 4 | 1 | 104 | 118 | 208 | 259 | 359 | 574 | 2588 | | **Total** | **40** | **1313** | **2626** | **11926** | **17005** | **23243** | **45868** | **173536** | ===== CATH-Plus Version 3.4 ===== **Based on PDB release: Nov 13, 2010** Changes since v3.3: * 24,232 newly assigned domains * 163 new homologous superfamilies * 49 new folds (topologies) The table below summarises the number of clusters within each of the four classes in CATH. ^ Class ^ Architecture ^ Topology ^ Homologous Superfamily ^ S35 Family ^ S60 Family ^ S95 Family ^ S100 Family ^ Domains ^ | 1 | 5 | 376 | 839 | 2763 | 3571 | 4679 | 9217 | 32396 | | 2 | 20 | 228 | 514 | 2514 | 3573 | 5668 | 9824 | 39140 | | 3 | 14 | 577 | 1082 | 5849 | 8381 | 10626 | 21900 | 79038 | | 4 | 1 | 101 | 114 | 204 | 253 | 352 | 547 | 2346 | | **Total** | **40** | **1282** | **2549** | **11330** | **15778** | **21325** | **41488** | **152920** | ===== CATH-Plus Version 3.3 ===== **Based on PDB release: July 7, 2009** Changes since v3.2: * 14,473 newly assigned domains * 199 new homologous superfamilies * 123 new folds (topologies) The table below summarises the number of clusters within each of the four classes in CATH. ^ Class ^ Architecture ^ Topology ^ Homologous Superfamily ^ S35 Family ^ S60 Family ^ S95 Family ^ S100 Family ^ Domains ^ | 1 | 5 | 360 | 773 | 2400 | 3092 | 4040 | 7838 | 26880 | | 2 | 14 | 558 | 1031 | 5151 | 7294 | 9192 | 18679 | 66456 | | 3 | 20 | 217 | 473 | 2283 | 3225 | 5002 | 8589 | 33469 | | 4 | 1 | 98 | 109 | 185 | 233 | 323 | 477 | 1883 | | **Total** | **40** | **1233** | **2386** | **10019** | **13844** | **18557** | **35583** | **128688** | ===== CATH-Plus Version 3.2 ===== **Based on PDB release: July 14, 2008** The v3.2.0 release of CATH has a number of improvements in the backend data and the frontend web pages. Changes since v3.1: * 20,330 newly assigned domains * 87 new homologous superfamilies * 26 new folds (topologies) The table below summarises the number of clusters within each of the four classes in CATH. ^ Class ^ Architecture ^ Topology ^ Homologous Superfamily ^ S35 Family ^ S60 Family ^ S95 Family ^ S100 Family ^ Domains ^ | 1 | 5 | 310 | 682 | 2078 | 2689 | 3540 | 6685 | 23491 | | 2 | 20 | 196 | 438 | 2062 | 2902 | 4468 | 7656 | 29992 | | 3 | 14 | 512 | 956 | 4558 | 6473 | 8135 | 16346 | 58967 | | 4 | 1 | 92 | 102 | 173 | 217 | 301 | 445 | 1765 | | **Total** | **40** | **1110** | **2178** | **8871** | **12281** | **16444** | **31132** | **114215** | ===== CATH-Plus Version 3.1 ===== **Based on PDB release: 14 Jan, 2007** We spent a great deal of effort identifying and correcting errors such as incorrectly chopped chains and misassigned domains. This meant that a number of homologous superfamilies (and folds) were merged with other nodes or removed as CATH domains were rechopped or reassigned. Changes since v3.0: * 7,734 newly assigned domains * 47 homologous superfamilies were merged or removed * 26 folds (topologies) were merged or removed The table below summarises the number of clusters within each of the four classes in CATH. ^ Class ^ Architecture ^ Topology ^ Homologous Superfamily ^ S35 Family ^ S60 Family ^ S95 Family ^ S100 Family ^ Domains ^ | 1 | 5 | 305 | 652 | 1850 | 2329 | 3001 | 5587 | 19729 | | 2 | 20 | 191 | 415 | 1860 | 2531 | 3846 | 6503 | 25537 | | 3 | 14 | 496 | 922 | 3922 | 5303 | 6659 | 12998 | 47193 | | 4 | 1 | 92 | 102 | 162 | 200 | 275 | 403 | 1426 | | **Total** | **40** | **1084** | **2091** | **7794** | **10363** | **13781** | **25491** | **93885** | ===== CATH-Plus Version 3.0 ===== **Based on PDB release: 5 May, 2006** ^ Class ^ Architecture ^ Topology ^ Homologous Superfamily ^ S35 Family ^ S60 Family ^ S95 Family ^ S100 Family ^ Domains ^ | 1 | 5 | 316 | 674 | 1877 | 2280 | 2862 | 5207 | 18271 | | 2 | 20 | 195 | 428 | 1843 | 2436 | 3653 | 6152 | 23482 | | 3 | 14 | 506 | 941 | 3956 | 5103 | 6239 | 12184 | 43025 | | 4 | 1 | 93 | 104 | 165 | 197 | 267 | 387 | 1373 | | **Total** | **40** | **1110** | **2147** | **7841** | **10016** | **13021** | **23930** | **86151** |