Table of Contents

CATH Release Notes

The CATH database is constantly being updated through automated algorithms and manual curation.

The most up-to-date annotations can be found in the CATH daily snapshots where we provide a limited amount of information (domain boundaries and superfamily assignments) for the very latest snapshot of the current database.

We also provide major releases (CATH-Plus) where we take a branch of the database through the full release process: adding internal checks, associating functional and sequence annotations, creating datasets, and so on.

Information from all releases can be downloaded from the Download page, general stats on each CATH-Plus release is provided below.

CATH-Plus Version 4.3

Based on PDB release: July 01, 2019

Changes since v4.2:

Class Architecture Topology Homologous Superfamily S35 Family S60 Family S95 Family S100 Family Domains
Class 1 5 404 2033 7817 10238 13421 26121 103788
Class 2 21 244 1290 6998 9877 16235 29211 124032
Class 3 14 634 2337 16373 24356 31614 64907 262275
Class 4 1 108 181 386 497 676 1112 5716
Class 6 2 82 790 814 867 969 1376 4427
TOTAL 41 1390 6631 32388 45835 62915 122727 500238

CATH-Plus Version 4.2

Based on PDB release: July 01, 2017

Changes since v4.1:

Class Architecture Topology Homologous Superfamily S35 Family S60 Family S95 Family S100 Family Domains
Class 1 5 405 2174 7771 9948 12797 24176 90302
Class 2 21 244 1395 7011 9627 15169 26904 110260
Class 3 14 634 2428 16196 23313 29670 60020 229776
Class 4 1 108 122 311 399 542 876 4519
TOTAL 41 1391 6119 31289 43287 58178 111976 434857

CATH-Plus Version 4.1

Based on PDB release: Jan 01, 2015

Changes since v4.0:

Class Architecture Topology Homologous Superfamily S35 Family S60 Family S95 Family S100 Family Domains
Class 1 5 396 908 4645 6190 8174 16299 61579
Class 2 20 241 547 4641 6639 10687 18460 78049
Class 3 14 628 1160 11617 17134 21834 44966 165745
Class 4 1 108 122 252 322 442 697 3626
TOTAL 40 1373 2737 21155 30285 41137 80422 308999

CATH-Plus Version 4.0

Based on PDB release: March 26, 2013

Changes since v3.5:

Class Architecture Topology Homologous Superfamily S35 Family S60 Family S95 Family S100 Family Domains
Class 1 5 397 907 3879 5118 6737 13368 48121
Class 2 20 241 547 3650 5221 8373 14526 58944
Class 3 14 626 1158 9171 13415 17047 35313 125772
Class 4 1 111 126 233 293 410 651 3021
TOTAL 40 1375 2738 16933 24047 32567 63858 235858

CATH-Plus Version 3.5

Based on PDB release: Sept 20, 2011

Changes since v3.4:

The table below summarises the number of clusters within each of the four classes in CATH.

Class Architecture Topology Homologous Superfamily S35 Family S60 Family S95 Family S100 Family Domains
1 5 386 875 2917 3843 5069 10098 37038
2 20 229 520 2618 3796 6147 10744 43881
3 14 594 1113 6183 9107 11668 24452 90029
4 1 104 118 208 259 359 574 2588
Total 40 1313 2626 11926 17005 23243 45868 173536

CATH-Plus Version 3.4

Based on PDB release: Nov 13, 2010

Changes since v3.3:

The table below summarises the number of clusters within each of the four classes in CATH.

Class Architecture Topology Homologous Superfamily S35 Family S60 Family S95 Family S100 Family Domains
1 5 376 839 2763 3571 4679 9217 32396
2 20 228 514 2514 3573 5668 9824 39140
3 14 577 1082 5849 8381 10626 21900 79038
4 1 101 114 204 253 352 547 2346
Total 40 1282 2549 11330 15778 21325 41488 152920

CATH-Plus Version 3.3

Based on PDB release: July 7, 2009

Changes since v3.2:

The table below summarises the number of clusters within each of the four classes in CATH.

Class Architecture Topology Homologous Superfamily S35 Family S60 Family S95 Family S100 Family Domains
1 5 360 773 2400 3092 4040 7838 26880
2 14 558 1031 5151 7294 9192 18679 66456
3 20 217 473 2283 3225 5002 8589 33469
4 1 98 109 185 233 323 477 1883
Total 40 1233 2386 10019 13844 18557 35583 128688

CATH-Plus Version 3.2

Based on PDB release: July 14, 2008

The v3.2.0 release of CATH has a number of improvements in the backend data and the frontend web pages.

Changes since v3.1:

The table below summarises the number of clusters within each of the four classes in CATH.

Class Architecture Topology Homologous Superfamily S35 Family S60 Family S95 Family S100 Family Domains
1 5 310 682 2078 2689 3540 6685 23491
2 20 196 438 2062 2902 4468 7656 29992
3 14 512 956 4558 6473 8135 16346 58967
4 1 92 102 173 217 301 445 1765
Total 40 1110 2178 8871 12281 16444 31132 114215

CATH-Plus Version 3.1

Based on PDB release: 14 Jan, 2007

We spent a great deal of effort identifying and correcting errors such as incorrectly chopped chains and misassigned domains. This meant that a number of homologous superfamilies (and folds) were merged with other nodes or removed as CATH domains were rechopped or reassigned.

Changes since v3.0:

The table below summarises the number of clusters within each of the four classes in CATH.

Class Architecture Topology Homologous Superfamily S35 Family S60 Family S95 Family S100 Family Domains
1 5 305 652 1850 2329 3001 5587 19729
2 20 191 415 1860 2531 3846 6503 25537
3 14 496 922 3922 5303 6659 12998 47193
4 1 92 102 162 200 275 403 1426
Total 40 1084 2091 7794 10363 13781 25491 93885

CATH-Plus Version 3.0

Based on PDB release: 5 May, 2006

Class Architecture Topology Homologous Superfamily S35 Family S60 Family S95 Family S100 Family Domains
1 5 316 674 1877 2280 2862 5207 18271
2 20 195 428 1843 2436 3653 6152 23482
3 14 506 941 3956 5103 6239 12184 43025
4 1 93 104 165 197 267 387 1373
Total 40 1110 2147 7841 10016 13021 23930 86151