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--- glossary:four_helix_bundle [2008/08/11 10:13]
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+++ glossary:four_helix_bundle [2008/09/17 07:52] (current)
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+{{tag>alpha}}
+====== Four Helix Bundle =======
+Four [[glossary:alpha_helix | helix]] bundles are a common structural [[glossary:motif | motif]] or architecture
+that has been extensively documented. They can be observed both independently and as components of larger folding units. The motif comprises four helices
+packed together in a variety of different ways, forming a hydrophobic core. In the most common
+bundles, the helices that are adjacent in the amino acid sequence are also adjacent in the
+three dimensional structure, forming the so-called up-down-up-down four helix bundle.
+The side chains of each helix in the bundle are arranged
+such that the hydrophobic side chains are buried between the helices and the hydrophilic
+side chains are exposed on the surface of the bundle.
+The example shown is a transferase (CATH domain ID 1tqgA00).
+{{cath:feature>1tqgA00}}
+===== References =====
+{{pubmed>long:1323830}}
+{{pubmed>long:3380793}}
+{{pubmed>long:2771946}}
+{{pubmed>long:8388289}}
+{{pubmed>long:6251384}}