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| + | {{tag>structure}} | ||
| + | ====== Loop ======= | ||
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| + | A protein loop is any stretch of non-regular polypeptide chain connecting | ||
| + | secondary structures. | ||
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| + | __Short loops__ commonly have little structure and are often found joining two adjacent [[glossary:beta_strand | beta strands ]]. They are often referred to as reverse turns. | ||
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| + | __Long loops__ are often flexible and are able to adopt a number of different conformations, effectively making them invisible in x-ray crystal structures. These loops are likely to be involved in protein function and can switch from a 'open' conformation (frequently to allow access to an active site) to a 'closed' conformation (to protect reactive groups from bulk solvent). | ||
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| + | ===== References ===== | ||
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| + | {{pubmed>long:4010788}} | ||
| + | {{pubmed>long:8819975}} | ||
| + | {{pubmed>long:3775366}} | ||
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