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====== CATH Release Notes ======

The CATH database is constantly being updated through automated algorithms and manual curation.

The most up-to-date annotations can be found in the [[data:index | CATH daily snapshots]] where we provide a limited amount of information (domain boundaries and superfamily assignments) for the very latest snapshot of the current database.

We also provide major releases (CATH-Plus) where we take a branch of the database
through the full release process: adding internal checks, associating functional and sequence annotations, 
creating datasets, and so on.

Information from all releases can be downloaded from the [[data:index| Download]] page, general stats on each CATH-Plus release is provided below.

===== CATH-Plus Version 4.2 =====

**Based on PDB release: July 01, 2017**

Changes since v4.1:

  * 125,858 newly classified domains
  * 24,765 newly processed PDBs

## Clusters by class

^ Class   ^ Architecture  ^ Topology  ^ Homologous Superfamily  ^ S35 Family  ^ S60 Family  ^ S95 Family  ^ S100 Family  ^ Domains  ^
| ------- | -- | ---- | ---- | ----- | ----- | ----- | ------ | ------ |
| Class 1 | 5  | 405  | 2174 | 7771  | 9948  | 12797 | 24176  | 90302  |
| Class 2 | 21 | 244  | 1395 | 7011  | 9627  | 15169 | 26904  | 110260 |
| Class 3 | 14 | 634  | 2428 | 16196 | 23313 | 29670 | 60020  | 229776 |
| Class 4 | 1  | 108  | 122  | 311   | 399   | 542   | 876    | 4519   |
| **TOTAL**   | **41** | **1391** | **6119** | **31289** | **43287** | **58178** | **111976** | **434857** |

===== CATH-Plus Version 4.1 =====

**Based on PDB release: Jan 01, 2015**

Changes since v4.0:

  * 73,141 newly classified domains
  * 17,444 newly processed PDBs


^ Class   ^ Architecture  ^ Topology  ^ Homologous Superfamily  ^ S35 Family  ^ S60 Family  ^ S95 Family  ^ S100 Family  ^ Domains  ^
| Class 1 | 5  | 396  | 908  | 4645  | 6190  | 8174  | 16299 | 61579  |
| Class 2 | 20 | 241  | 547  | 4641  | 6639  | 10687 | 18460 | 78049  |
| Class 3 | 14 | 628  | 1160 | 11617 | 17134 | 21834 | 44966 | 165745 |
| Class 4 | 1  | 108  | 122  | 252   | 322   | 442   | 697   | 3626   |
| **TOTAL** | **40** | **1373** | **2737** | **21155** | **30285** | **41137** | **80422** | **308999** |



===== CATH-Plus Version 4.0 =====

**Based on PDB release: March 26, 2013**

Changes since v3.5:

  * 62,322 newly assigned domains
  * 112 new homologous superfamilies
  * 62 new folds (topologies)

^ Class   ^ Architecture  ^ Topology  ^ Homologous Superfamily  ^ S35 Family  ^ S60 Family  ^ S95 Family  ^ S100 Family  ^ Domains  ^
| Class 1 | 5  | 397  | 907  | 3879  | 5118  | 6737  | 13368 | 48121  |
| Class 2 | 20 | 241  | 547  | 3650  | 5221  | 8373  | 14526 | 58944  |
| Class 3 | 14 | 626  | 1158 | 9171  | 13415 | 17047 | 35313 | 125772 |
| Class 4 | 1  | 111  | 126  | 233   | 293   | 410   | 651   | 3021   |
| **TOTAL** | **40** | **1375** | **2738** | **16933** | **24047** | **32567** | **63858** | **235858** |




===== CATH-Plus Version 3.5 =====

**Based on PDB release: Sept 20, 2011**

Changes since v3.4:

  * 20,616 newly assigned domains
  * 77 new homologous superfamilies
  * 31 new folds (topologies)

The table below summarises the number of clusters within each of the four classes in CATH.

^ Class   ^ Architecture  ^ Topology  ^ Homologous Superfamily  ^ S35 Family  ^ S60 Family  ^ S95 Family  ^ S100 Family  ^ Domains  ^
| 1       | 5  | 386 | 875  | 2917 | 3843 | 5069  | 10098 | 37038 |
| 2       | 20 | 229 | 520  | 2618 | 3796 | 6147  | 10744 | 43881 |
| 3       | 14 | 594 | 1113 | 6183 | 9107 | 11668 | 24452 | 90029 |
| 4       | 1  | 104 | 118  | 208  | 259  | 359   | 574   | 2588  |
| **Total** | **40** | **1313** | **2626** | **11926** | **17005** | **23243** | **45868** | **173536** | 


===== CATH-Plus Version 3.4 =====

**Based on PDB release: Nov 13, 2010**

Changes since v3.3:

  * 24,232 newly assigned domains
  * 163 new homologous superfamilies
  * 49 new folds (topologies)

The table below summarises the number of clusters within each of the four classes in CATH.

^ Class   ^ Architecture  ^ Topology  ^ Homologous Superfamily  ^ S35 Family  ^ S60 Family  ^ S95 Family  ^ S100 Family  ^ Domains  ^
| 1 | 5 | 376 | 839 | 2763 | 3571 | 4679 | 9217 | 32396 |
| 2 | 20 | 228 | 514 | 2514 | 3573 | 5668 | 9824 | 39140 |
| 3 | 14 | 577 | 1082 | 5849 | 8381 | 10626 | 21900 | 79038 |
| 4 | 1 | 101 | 114 | 204 | 253 | 352 | 547 | 2346 |
| **Total** | **40** | **1282** | **2549** | **11330** | **15778** | **21325** | **41488** | **152920** |

===== CATH-Plus Version 3.3 =====

**Based on PDB release: July 7, 2009**

Changes since v3.2:

  * 14,473 newly assigned domains
  * 199 new homologous superfamilies
  * 123 new folds (topologies)

The table below summarises the number of clusters within each of the four classes in CATH.

^ Class   ^ Architecture  ^ Topology  ^ Homologous Superfamily  ^ S35 Family  ^ S60 Family  ^ S95 Family  ^ S100 Family  ^ Domains  ^
| 1 | 5 | 360 | 773 | 2400 | 3092 | 4040 | 7838 | 26880 |
| 2 | 14 | 558 | 1031 | 5151 | 7294 | 9192 | 18679 | 66456 |
| 3 | 20 | 217 | 473 | 2283 | 3225 | 5002 | 8589 | 33469 |
| 4 | 1 | 98 | 109 | 185 | 233 | 323 | 477 | 1883 |
| **Total** | **40** | **1233** | **2386** | **10019** | **13844** | **18557** | **35583** | **128688** |


===== CATH-Plus Version 3.2 =====

**Based on PDB release: July 14, 2008**

The v3.2.0 release of CATH has a number of improvements in the backend data and the frontend web pages.

Changes since v3.1:

  * 20,330 newly assigned domains
  * 87 new homologous superfamilies
  * 26 new folds (topologies)

The table below summarises the number of clusters within each of the four classes in CATH.

^ Class   ^ Architecture  ^ Topology  ^ Homologous Superfamily  ^ S35 Family  ^ S60 Family  ^ S95 Family  ^ S100 Family  ^ Domains  ^
| 1 | 5 | 310 | 682 | 2078 | 2689 | 3540 | 6685 | 23491  |
| 2 | 20 | 196 | 438 | 2062 | 2902 | 4468 | 7656 | 29992  |
| 3 | 14 | 512 | 956 | 4558 | 6473 | 8135 | 16346 | 58967  |
| 4 | 1 | 92 | 102 | 173 | 217 | 301 | 445 | 1765  |
| **Total** | **40** | **1110** | **2178** | **8871** | **12281** | **16444** | **31132** | **114215**  |



===== CATH-Plus Version 3.1 =====

**Based on PDB release: 14 Jan, 2007**


We spent a great deal of effort identifying and correcting errors such as incorrectly chopped chains and misassigned domains. This meant that a number of homologous superfamilies (and folds) were merged with other nodes or removed as CATH domains were rechopped or reassigned.

Changes since v3.0:

  * 7,734 newly assigned domains
  * 47 homologous superfamilies were merged or removed
  * 26 folds (topologies) were merged or removed

The table below summarises the number of clusters within each of the four classes in CATH.

^ Class   ^ Architecture  ^ Topology  ^ Homologous Superfamily  ^ S35 Family  ^ S60 Family  ^ S95 Family  ^ S100 Family  ^ Domains  ^
| 1 | 5 | 305 | 652 | 1850 | 2329 | 3001 | 5587 | 19729  |
| 2 | 20 | 191 | 415 | 1860 | 2531 | 3846 | 6503 | 25537  |
| 3 | 14 | 496 | 922 | 3922 | 5303 | 6659 | 12998 | 47193  |
| 4 | 1 | 92 | 102 | 162 | 200 | 275 | 403 | 1426  |
| **Total** | **40** | **1084** | **2091** | **7794** | **10363** | **13781** | **25491** | **93885**  |



===== CATH-Plus Version 3.0 =====

**Based on PDB release: 5 May, 2006**


^ Class   ^ Architecture  ^ Topology  ^ Homologous Superfamily  ^ S35 Family  ^ S60 Family  ^ S95 Family  ^ S100 Family  ^ Domains  ^
| 1 | 5 | 316 | 674 | 1877 | 2280 | 2862 | 5207 | 18271  |
| 2 | 20 | 195 | 428 | 1843 | 2436 | 3653 | 6152 | 23482  |
| 3 | 14 | 506 | 941 | 3956 | 5103 | 6239 | 12184 | 43025  |
| 4 | 1 | 93 | 104 | 165 | 197 | 267 | 387 | 1373  |
| **Total** | **40** | **1110** | **2147** | **7841** | **10016** | **13021** | **23930** | **86151**  |
Trace: • sillitoe • beta_hairpin • index • motif • data • release_notes • eccb_t2_fundi • helix • alpha_beta_plait
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