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+ | {{tag>beta}} | ||
+ | |||
+ | |||
+ | ====== Beta Helix ======= | ||
+ | |||
+ | In this mainly beta fold, the polypeptide chain is wound into a large right-handed coil (or super helix). | ||
+ | There are two different types of beta helix, one with two [[glossary:beta_sheet | beta sheets]], and one with three beta | ||
+ | sheets. In our classification scheme we describe these as 2-solenoid and 3-solenoid beta | ||
+ | [[glossary:architecture | architectures]], respectively. | ||
+ | |||
+ | __2-solenoid__ | ||
+ | |||
+ | This architecture comprises of two flat beta sheets | ||
+ | packed tightly against one another. It has a highly | ||
+ | distinctive and repetitive [[glossary:beta_strand | strand]] connectivity, | ||
+ | which distinguishes it from the two layer sandwich architecture. | ||
+ | The chain continually alternates between the two sheet layers whilst progressing in a | ||
+ | spiraling motion from one end of the structure to the other, hence the | ||
+ | term 'solenoid.' This could also be classified as a 2-layer beta sandwich but | ||
+ | its unusual lack of curvature and its unusual topology have led to it being | ||
+ | identified separately. | ||
+ | |||
+ | __3-solenoid__ | ||
+ | |||
+ | Structures with this architecture comprise three beta sheets which | ||
+ | have a distinctive strand connectivity. The chain visits each sheet | ||
+ | in turn and is progressively wound around the principal axis in | ||
+ | the same direction. | ||
+ | |||
+ | ===== References ===== | ||
+ | |||
+ | {{pubmed>long:8081735}} | ||
+ | {{pubmed>long:8081738}} | ||
+ | |||