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+ | {{tag>beta}} | ||
+ | ====== Jelly Roll ======= | ||
+ | |||
+ | This is a fold topology that classically consists of four | ||
+ | Greek key [[glossary: motif | motifs]] that adopt an eight-stranded [[glossary:beta_sandwich | beta sandwich ]] structure. In this fold the [[glossary:hydrogen_bond | hydrogen bonding]] | ||
+ | pattern between adjacent strands is broken in two places, and as a consequence the | ||
+ | structure comprises two four-stranded beta sheets. Both sheets are purely antiparallel, | ||
+ | with strands adjacent in sequence appearing in different sheets with the exception of the | ||
+ | fourth and fifth strands, which are in the same sheet. This leads to a structure with only | ||
+ | one hairpin; all other beta-beta connections are arches. When the structure is depicted | ||
+ | in two-dimensions the origin of its name is apparent: the structure resembles a jelly roll (Swiss roll). | ||
+ | |||
+ | {{ :glossary:jelly_roll2.gif?800 |}} | ||
+ | |||
+ | In theory there are four types of jellyroll folds: two | ||
+ | have a right-handed superhelical twist, and two have a left handed twist. However, as | ||
+ | with the [[glossary:beta_alpha_beta_motif | beta-alpha-beta motif ]], only right-handed [[glossary:greek_key | Greek key]] | ||
+ | and jellyroll structures are actually observed in globular proteins. In practise, | ||
+ | the jelly roll may be varied by the addition or deletion of secondary | ||
+ | structure elements. | ||
+ | |||
+ | The example shown is a the carboxy-terminal domain of phosphomannose isomerase (CATH domain ID 1pmiA03). | ||
+ | |||
+ | {{cath:feature>1pmiA03}} | ||
+ | |||
+ | |||
+ | ===== References ===== | ||
+ | |||
+ | {{pubmed>long:1644197}} |