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glossary:jelly_roll [2008/08/11 10:59]
cuff
glossary:jelly_roll [2008/09/19 08:05] (current)
garner
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 +
 +
 +{{tag>beta}}
 +======  Jelly Roll  =======
 +
 +This is a fold topology that classically consists of four
 +Greek key [[glossary: motif | motifs]] that adopt an eight-stranded [[glossary:beta_sandwich | beta sandwich ]] structure.  In this fold the [[glossary:hydrogen_bond | hydrogen bonding]]
 +pattern between adjacent strands is broken in two places, and as a consequence the
 +structure comprises two four-stranded beta sheets. Both sheets are purely antiparallel,
 +with strands adjacent in sequence appearing in different sheets with the exception of the
 +fourth and fifth strands, which are in the same sheet. This leads to a structure  with only
 +one hairpin; all other beta-beta connections are arches. When the structure is depicted
 +in two-dimensions the origin of its name is apparent: the structure resembles a jelly roll (Swiss roll).
 +
 +{{ :glossary:jelly_roll2.gif?800 |}}
 +
 +In theory there are four types of jellyroll folds: two
 +have a right-handed superhelical twist, and two have a left handed twist. However, as
 +with the [[glossary:beta_alpha_beta_motif | beta-alpha-beta motif ]], only right-handed [[glossary:greek_key | Greek key]]
 +and jellyroll structures are actually observed in globular proteins. In practise,
 +the jelly roll may be varied by the addition or deletion of secondary
 +structure elements.
 +
 +The example shown is a the carboxy-terminal domain of phosphomannose isomerase (CATH domain ID 1pmiA03).
 +
 +{{cath:feature>1pmiA03}}
 +
 +
 +===== References =====
 +
 +{{pubmed>long:1644197}}
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