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glossary:loop [2008/08/07 15:07]
cuff 		glossary:loop [2008/09/19 11:39] (current)
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 +{{tag>structure}}
 +====== Loop =======
 +
 +A protein loop is any stretch of non-regular polypeptide chain connecting
 +secondary structures.
 +
 +__Short loops__ commonly have little structure and are often found joining two adjacent [[glossary:beta_strand | beta strands ]]. They are often referred to as reverse turns. 
 +
 +__Long loops__ are often flexible and are able to adopt a number of different conformations, effectively making them invisible in x-ray crystal structures. These loops are likely to be involved in protein function and can switch from a 'open' conformation (frequently to allow access to an active site) to a 'closed' conformation (to protect reactive groups from bulk solvent).
 +
 +===== References =====
 +
 +{{pubmed>long:4010788}}
 +{{pubmed>long:8819975}}
 +{{pubmed>long:3775366}}
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